Credits

• 2025 · Play Dirty as Lozini
• 2023 · Mr. Monk's Last Case: A Monk Movie as Adrian Monk
• 2023 · Linoleum as Dr. Alvin
• 2020 · Peacock Presents: The At-Home Variety Show Featuring Seth MacFarlane as Adrian Monk / Self
• 2018 · Rosy as Dr. Godin
• 2017 · Final Portrait as Diego Giacometti
• 2016 · The Assignment as Dr. Ralph Galen
• 2016 · Custody as Jason Schulman
• 2014 · The Radiator Springs 500½ as Luigi (voice)
• 2013 · We Are Men as Frank Russo
• 2013 · Hiccups as Luigi (voice)
• 2013 · Spinning as Luigi (voice)
• 2012 · Hemingway & Gellhorn as Mikhail Koltsov
• 2011 · Too Big to Fail as John Mack
• 2010 · How Do You Know as Psychiatrist
• 2005 · The Naked Brothers Band: The Movie as Tony Shalhoub
• 2004 · The Last Shot as Tommy Sanz
• 2004 · Against the Ropes as Sam LaRocca
• 2002 · Life or Something Like It as Jack
• 2001 · Impostor as Nelson Gittes
• 1998 · The Impostors as Voltri, First Mate
• 1997 · A Life Less Ordinary as Al
• 1996 · Big Night as Primo
• 1995 · MADtv as Taxi Cab Driver
• 1995 · MADtv as Self
• 1994 · I.Q. as Bob Rosetti
• 1994 · Gypsy as Uncle Jocko
• 1993 · Searching for Bobby Fischer as Chess Club Member
• 1992 · Honeymoon in Vegas as Buddy Walker
• 1990 · Quick Change as Cab Driver
• 1989 · Longtime Companion as Paul's Doctor
• Future · Cars: Lightning Racers as Luigi (voice)
• 2025 · Tony Shalhoub Breaking Bread as Self
• 2025 · Radiator Springs Racers | Disneyland Resort as Luigi (voice)
• 2023 · Flamin' Hot as Roger Enrico
• 2022 · The Jennifer Hudson Show as
• 2022 · Cars on the Road as Luigi (voice)
• 2022 · Way of Tomorrow: The Evolution of Science Fiction Movies as Self - (archive footage)
• 2021 · Rumble as Fred (voice)
• 2020 · Central Park as Marvin (voice)
• 2020 · Stars in the House as Self
• 2019 · Never Surrender: A Galaxy Quest Documentary as Self
• 2019 · A Little Late with Lilly Singh as Self
• 2019 · The Kelly Clarkson Show as Self
• 2019 · Under A Rock with Tig Notaro as Self - Guest
• 2017 · They Shall Not Perish as Karnig Parnian
• 2017 · Cars 3 as Luigi (voice)
• 2017 · The Marvelous Mrs. Maisel as Abe Weissman
• 2017 · Breakable You as Adam Weller
• 2016 · BrainDead as Senator Red Wheatus
• 2016 · Teenage Mutant Ninja Turtles: Out of the Shadows as Splinter (voice)
• 2016 · Must See TV: An All Star Tribute to James Burrows as Self
• 2015 · Act One: Live from Lincoln Center as Moss Hart / Barnett Hart / George S. Kaufman
• 2015 · Guns for Hire as Parking Violations Bureau Agent
• 2015 · Close Up with The Hollywood Reporter as Self
• 2014 · Teenage Mutant Ninja Turtles as Splinter (voice)
• 2014 · Blow Me as Self
• 2014 · Late Night with Seth Meyers as Self - Guest
• 2013 · The Blacklist as Alistair Pitt
• 2013 · Find Our Daughter as Father
• 2013 · Valentino's Ghost as Self
• 2013 · Pain & Gain as Victor Kershaw
• 2012 · Men in Black 3 as 1969 Newsstand Vendor (uncredited)
• 2012 · Finding Your Roots as Self
• 2011 · Caris' Peace as Self
• 2011 · Five as Mitch
• 2011 · Cars 2 as Luigi (voice)
• 2011 · Feed the Fish as Sheriff Andersen
• 2010 · Solartaxi: Around the World with the Sun as
• 2009 · Nurse Jackie as Dr. Bernard Prince
• 2008 · AmericanEast as Sam
• 2008 · Free Radio as Tony Shalhoub
• 2007 · 1408 as Sam Farrell
• 2007 · Careless as Mr. Roth
• 2006 · Geared-Up as
• 2006 · Cars as Luigi (voice)
• 2006 · Sacco and Vanzetti as Sacco (Voice)
• 2005 · The Great New Wonderful as Dr. Trabulous
• 2004 · The Tony Danza Show as Self
• 2003 · Party Animals as Celeb Father
• 2003 · Spy Kids 3-D: Game Over as Alexander Minion
• 2003 · Jimmy Kimmel Live! as Self
• 2003 · MythBusters as Self
• 2002 · Spy Kids 2: The Island of Lost Dreams as Alexander Minion
• 2002 · Monk as Adrian Monk
• 2002 · Men in Black II as Jeebs
• 2002 · Making "The Man Who Wasn't There" as Self
• 2002 · Made-Up as Max Hires
• 2001 · The Man Who Wasn't There as Freddy Riedenschneider
• 2001 · Thir13en Ghosts as Arthur
• 2001 · Good Day Live as Self
• 2001 · Spy Kids as Alexander Minion
• 2001 · The Heart Department as Dr. Joseph Nassar
• 1999 · Galaxy Quest as Fred Kwan
• 1999 · Stark Raving Mad as Ian Stark
• 1999 · That Championship Season as George Sitkowski
• 1998 · A Civil Action as Kevin Conway
• 1998 · The Siege as Agent Frank Haddad
• 1998 · The Tic Code as Phil
• 1998 · Paulie as Misha Vilyenkov
• 1998 · Primary Colors as Eddie Reyes
• 1997 · Men in Black: The Series as Jeebs (voice)
• 1997 · Ally McBeal as Albert Shepley
• 1997 · The View as Self
• 1997 · Gattaca as "German"
• 1997 · Men in Black as Jeebs
• 1996 · The Rosie O'Donnell Show as Self - Guest
• 1996 · Radiant City as Narrator
• 1995 · Almost Perfect as
• 1994 · Gargoyles as The Emir (voice)
• 1993 · Addams Family Values as Jorge
• 1993 · Frasier as Manu
• 1993 · Late Night with Conan O'Brien as Self - Guest
• 1993 · The X-Files as Dr. Chester Ray Banton
• 1991 · Barton Fink as Ben Geisler
• 1991 · Dinosaurs as Jerry Valentine (voice)
• 1990 · Wings as Antonio Scarpacci
• 1989 · Money, Power, Murder. as Seth Parker
• 1989 · Day One as Enrico Fermi
• 1988 · Monsters as Officer Mancini
• 1988 · LIVE with Kelly and Mark as
• 1988 · LIVE with Kelly and Mark as Self - Guest
• 1988 · Alone in the Neon Jungle as Nahid
• 1986 · Heartburn as Airplane Passenger (uncredited)
• 1985 · Spenser: For Hire as
• 1985 · The Equalizer as Terrorist Leader
• Future · Bolio: Spirit of the Mustang as
• Future · The Wonder Yard as Yusuf